Lymphoma as presentation of common variable immunodeficiency.
نویسندگان
چکیده
taxenes, platinum salts, L-asparaginase and monoclonal antibodies involving anaphylactic or anaphylactoid reactions. To date no desensitisation protocols have been published on third generation aromatase inhibitors like AN. In these case reports both patients referred late reactions to AN with mainly cutaneous symptoms. To clarify the underlying mechanism of these reactions, patch tests with 10 % AN in white petrolatum were performed with negative results. This could have several explanations: the fi nal responsible agent for the reaction could be a metabolite of AN; poor penetration of the drug into the epidermis; low drug concentration, use of inappropriate vehicle and immunosuppression state of patients. Although no immune mechanism could be proven in our patients, a desensitisation procedure was tried with success. This result reinforces the fact that desensitisation to drugs that induce delayed cutaneous hypersensitivity reactions is possible and safe, as we have observed many times in patients with HIV infection and delayed cutaneous reactions to cotrimoxazol.
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ورودعنوان ژورنال:
- Allergologia et immunopathologia
دوره 37 1 شماره
صفحات -
تاریخ انتشار 2009